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Redox Signaling

Redox Signaling refers to the procedure in which free radicals, reactive oxygen species and other electronically activated radicals act as messengers in the biological system. It's basically the process that displays how cells in our body respond to oxidants and free radicals. Redox signaling is a consistent and important process, through which human cells communicate with each other and carry out important body functions.

What are Redox Signaling Molecules?

There are 2 types of Signaling molecules - "activator" and "communicator". These two play the role of messengers and are accountable for the communication between cells throughout our body. Also known as Signaling molecules, they switch on the body's antioxidant compounds - Glutathione, SOD and Catalase.

In simpler terms, Redox signaling molecules are substances that are produced organically within each cell of the body.

When the cells are necessary to perform various functions, they generate 2 types of signaling molecules.

The first set of "activator" molecules trigger the antioxidants stored in the body. Antioxidants are very effective in fighting off the impairment caused by free radicals and oxidative stress; however they cannot function unless activated by the signaling molecules. Hence you require the Redox signaling 'activator' molecules to make the antioxidants to work.

The 2nd set of "communicator" molecules is responsible for enabling proper communication between the cells of the body, making sure optimum performance of the immune system and safeguarding the body against external stimuli such as harmful viruses, bacteria etc. The millions of cells in our body are able to properly function and communicate because of the Redox signaling molecules.

Why is Redox signaling so essential?

Both the external and internal factors such as toxic chemicals, stress poor nutrition, bacterial infections etc affect our health in an undesirable way.

This causes considerable cellular damage and a reduction in Redox signaling molecules. Without an adequate supply of Redox signaling molecules the antioxidants and immune system are unable to function effectively, contributing to a vast range of health ailments.

Researchers and researchers worldwide have been conducting several studies on the Redox signaling molecules to find out more about their structure, effect and function with respect to human health. Let's take a look at many of the popular studies on this subject:

Blue-eyed, White Cats are Deaf

Charles Darwin, the father of evolution had stated "white cats with blue eyes are almost deaf". He proposed that developmental issues with the nervous system might be the cause of deafness in the white, blue-eyed cats. But researchers think it has something to do with the Redox signaling process, as Central nervous system growth is a messenger-mediated procedure and so is the melanin synthesis.

Thus an imbalance in the Redox signaling process leads to improper melanin synthesis (giving the cat its white color) and results in defective intra-cellular communication (causing hearing impairment).

Study by Hoffer and Osmond

The very first instance of Redox processes being engaged in cell signaling was given by Hoffer and Osmond. As per the Adrenochrome hypothesis, "psychoactive oxidative products of catecholamines (adrenochromes) play a part in schizophrenia and other neuropsychiatric diseases". Although the proposed hypothesis still remains in question, the simple fact that messenger-mediated oxidative stress can lead to neuropsychiatric diseases, has been proven correct.

Function of Active Oxygen Species in Ocular and Neurological Conditions

According to a study byP. H. Proctor, D.S Kirpatrick, J.E. McGinness, L.A Morehead, J.G. Hilton, & J.A. Hokanson on the function of active oxygen species in neurological disorders, "Electronically activated oxygen molecules like peroxide or superoxide are identified to be the substantial factors accountable for certain disorders of the eye and nervous system. For example, a person with high levels of homocysteine or copper often shows four characteristic signs - psychotic behavior, movement disorders, deafness and pigmentary abnormalities. Both copper and homocysteine act as catalysts in the production of reactive oxygen molecules, and the above mentioned abnormalities can be a result of the Redox signaling process brought on by these reactive molecules."

This concept suggests that active oxygen species act as specific intermediary transmitters for a variety of biological processes including inflammation and fibrosis.

Aging is also attributed to this kind of free radical destruction. The cells are not completely destroyed, but become less efficient. Too numerous oxidative molecules present in the blood and skin cells causes damage and aging. Improper balance of Redox signaling molecules triggers the immune system to attack healthy cells, which divide and further spread the damage.

In Conclusion:

Cells are destroyed by factors like sunlight, environmental pollution, toxins, chemicals, infections and other irritants. Damaged cells build up free radicals or oxidants. As a component of the Redox signaling process, the activator molecules set off the antioxidants that neutralize the free radicals and maintain a balance of oxidative molecules in the body. Furthermore the signaling molecules ensure that the immune system and cellular communication is functioning at ideal levels.

A lack of Redox signaling molecules disturbs this entire process - the stability of activated oxygen molecules is destroyed, resulting in cellular damage and other health problems.

Redox signaling is a widespread and important process governing important cellular activities, and there's an urgent need for new methods of research to assess the role of Redox molecules at the cellular and mulecular level. With more products that can recover the stability of Redox molecules in the body, we would have solutions and answers for a wide variety of physical and neurological ailments. ASEA is one of those products. It is actually the only perfectly balanced mixture of stabilized Redox Signaling molecules that exists outside the body.